Synthesis of isomeric nucleoside phosphonates: Cyclic analogs of the anti-HIV active compound, PMEA

Article abstract of DOI:10.1016/S0040-4020(99)00681-X

Synthesis of cyclic analogs of the anti-HIV active acyclic nucleoside phosphonate, PMEA is described. A key reaction in the synthesis was the stereoselective cyclization of an acyclic phosphonyl intermediate to a phosphonyltetrahydrofuran. Complete stereo