Asymmetric synthesis of arylglycine amino acids using (S,S)-(+)- pseudoephedrine derived amides

Article abstract of DOI:10.1016/S0040-4039(99)01475-6

Arylglycine aminoacids were obtained in good yields and with enantiomeric excesses higher than 99% by using an asymmetric amination reaction protocol on (S,S)-(+)-pseudoephedrine based arylacetamide enolates with di-tert-butylazodicarboxylate. Subsequent hydrazinolysis and hydrolysis yielded the target aminoacids.