Bioorganic and Medicinal Chemistry Letters p. 2497 - 2502 (1999)
Update date:2022-08-03
Topics:
Cody, Wayne L.
Cai, Cuiman
Doherty, Annette M.
Edmunds, Jeremy J.
He, John X.
Narasimhan, Lakshmi S.
Plummer, Janet S.
Rapundalo, Stephen T.
Rubin, J. Ronald
Van Huis, Chad A.
Yves, St-Denis
Winocour, Peter D.
Siddiqui, M. Arshad
Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described.
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