Tetrahedron p. 11833 - 11842 (1999)
Update date:2022-09-26
Topics:
Gros, Christel
Galeotti, Nathalie
Pascal, Robert
Jouin, Patrick
Solid phase synthesis of Ψ[CH2NH] pseudopeptide 3 was accomplished by reductive amination of peptidyl aldehyde 1 with resin bound amino peptide 2. No epimerization took place during the aldehyde preparation or the reductive amination step. This convergent strategy should facilitate the synthesis of analogues of the neuropeptide PACAP.
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