Chemical and Pharmaceutical Bulletin p. 1276 - 1283 (1999)
Update date:2022-08-02
Topics:
Jinno, Shuji
Otsuka, Naomi
Okita, Takaaki
Inouye, Kuniyo
A total synthesis of benzodioxole derivative 1 was achieved via a palladium(0)-catalyzed cross-coupling reaction in a 68% overall yield (4 steps). A novel series of benzodioxoles bearing a variety of aromatic and heterocyclic rings was also prepared and the antioxidative activity evaluated using in vitro model systems. Structure-activity studies revealed that i) intramolecular hydrogen-bonding in the phenol moiety reduced activity, ii) introduction of disubstituents at the ortho location relative to the phenol increased activity, and iii) the methylenedioxy function contributed to stabilization of the phenoxy radical. Among of these compounds, 5,7-di-(4- methoxyphenyl)-4-methoxy-6-hydroxy-1,3-benzodioxole (7p) was the most favorable agent and more potent than n-propyl gallate.
View MoreTaixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD
website:http://www.jinjingroup.com
Contact:4009982989
Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
Hangzhou Zhenghan Biological Technology Co., Ltd.
Contact:86-571-88781753
Address:liangzhu yuhang hangzhou city
Tangshan Wisdom Trading Co.,Ltd
Contact:86 315 2222979
Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Doi:10.1021/ja00153a003
(1995)Doi:10.1021/ja950745i
(1996)Doi:10.1007/BF01166333
(1995)Doi:10.1016/S0040-4039(00)91776-3
(1993)Doi:10.1016/0040-4039(95)01829-7
(1995)Doi:10.1016/0040-4039(95)01877-K
(1995)