SYNTHESIS OF N-(ω-TRIMETHYLSILYLALKYL)PURINES UNDER CONDITIONS OF INTERFACIAL CATALYSIS

Article abstract of DOI:10.1007/BF01166333

A method of synthesis of N-(ω-trimethylsilylalkyl)purines, by alkylation of potassium salts of purine bases by 3-chloropropyltrimethylsilane and chloromethyltrimethylsilanes under conditions of interfacial catalysis, has been developed.Hydroxylation of the N-allyl group by dimethylphenylsilane, which is an alternative pathway of synthesis of silicon-containing purine derivatives, has been accomplished for the first time in the purine series.The structure of the compounds obtained was established by methods of PMR and UV spectroscopy.