Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

DOI: 10.1016/S0960-894X(01)00331-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1943 - 1945 (2001)

Update date:2022-07-30

Topics:

Authors:

Patel, Mona

McHugh Jr., Robert J

Cordova, Beverly C.

Klabe, Ronald M.

Bacheler, Lee T.

Erickson-Viitanen, Susan

Rodgers, James D.

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Article abstract of DOI:10.1016/S0960-894X(01)00331-6

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.

Full text of DOI:10.1016/S0960-894X(01)00331-6

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