Synthesis of new nucleoside analogues comprising a geminal difluorocyclopropane moiety as potential antiviral/antitumor agents

Article abstract of DOI:10.1080/07328319908044881

Geminal difluorocyclopropane analogues of nucleosides 7a - 7e were synthesized. Compounds 7a and 7c - 7e were obtained by alkylation of nucleic acid bases or their appropriate precursors with (cis)-1- benzyloxymethyl-2-bromomethyl-3,3-difluorocyclopropane (8). Analogue 7b was prepared by hydrolysis of 2-amino-6-chloropurine derivative 7e. Compounds 7a - 7d did not exhibit any antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1 or antitumor effects against murine leukemia L1210, mouse tumors PO3 or C38 and human tumor H15.

Full text of DOI:10.1080/07328319908044881

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Synthesis of New Nucleoside
Analogues Comprising a Geminal
Difluorocyclopropane Moiety as Potential
Antiviral/Antitumor Agents
Yao-Ling Qiu a & Jiri Zemlicka a
a Department of Chemistry, Experimental and Clinical Therapeutics
Program, Barbara Ann Karmanos Cancer Institute, Wayne State
University School of Medicine, Detroit, Michigan, 48201-1379
Published online: 04 Oct 2006.
To cite this article: Yao-Ling Qiu & Jiri Zemlicka (1999): Synthesis of New Nucleoside Analogues
Comprising a Geminal Difluorocyclopropane Moiety as Potential Antiviral/Antitumor Agents,
Nucleosides and Nucleotides, 18:10, 2285-2300
To link to this article: http://dx.doi.org/10.1080/07328319908044881
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