Bioorganic and Medicinal Chemistry Letters p. 3211 - 3216 (1999)
Update date:2022-07-30
Topics: Synthesis Piperidine Biological Evaluation Experimental
Hoepping, Alexander
Babich, John
Zubieta, Jon A.
Johnson, Kenneth M.
Machill, Susanne
Kozikowski, Alan P.
Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.
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Doi:10.1016/S0968-0896(99)00186-8
(1999)Doi:10.1016/S0960-894X(00)00295-X
(2000)Doi:10.1002/chem.201202607
(2012)Doi:10.1039/b917056a
(2010)Doi:10.1039/c9cc06676d
(2019)Doi:10.3390/molecules21060671
(2016)
