Bioorganic and Medicinal Chemistry Letters p. 3211 - 3216 (1999)
Update date:2022-07-30
Topics: Synthesis Piperidine Biological Evaluation Experimental DAT-binding Technetium complexes Cocaine analogue
Hoepping, Alexander
Babich, John
Zubieta, Jon A.
Johnson, Kenneth M.
Machill, Susanne
Kozikowski, Alan P.
Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.
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Doi:10.1016/S0968-0896(99)00186-8
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(2012)Doi:10.1039/b917056a
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