Bioorganic and Medicinal Chemistry Letters p. 3301 - 3306 (1999)
Update date:2022-07-30
Topics:
Dinsmore, Christopher J.
Williams, Theresa M.
O'Neill, Timothy J.
Liu, Dongming
Rands, Elaine
Culberson, J. Christopher
Lobell, Robert B.
Koblan, Kenneth S.
Kohl, Nancy E.
Gibbs, Jackson B.
Oliff, Allen I.
Graham, Samuel L.
Hartman, George D.
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically
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Doi:10.1080/00397910802546177
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(2000)Doi:10.1007/BF01181909
(1988)
