Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

DOI: 10.1016/S0960-894X(99)00605-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3301 - 3306 (1999)

Update date:2022-07-30

Topics:

Authors:

Dinsmore, Christopher J.

Williams, Theresa M.

O'Neill, Timothy J.

Liu, Dongming

Rands, Elaine

Culberson, J. Christopher

Lobell, Robert B.

Koblan, Kenneth S.

Kohl, Nancy E.

Gibbs, Jackson B.

Oliff, Allen I.

Graham, Samuel L.

Hartman, George D.

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Article abstract of DOI:10.1016/S0960-894X(99)00605-8

The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically

Full text of DOI:10.1016/S0960-894X(99)00605-8

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