Bioorganic and Medicinal Chemistry p. 2427 - 2436 (1999)
Update date:2022-08-04
Topics:
Breslin, Henry J.
Kukla, Michael J.
Kromis, Teresa
Cullis, Heather
De Knaep, Fons
Pauwels, Rudi
Andries, Koen
De Clercq, Erik
Janssen, Marcel A.C.
Janssen, Paul A.J.
4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)- ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication, as reported in detail in our prior publications. Since our earlier reports, we have modified the TIBO structu
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