
Chemical and Pharmaceutical Bulletin p. 1790 - 1793 (1999)
Update date:2022-07-30
Topics:
Natsuka, Kagayaki
Nishikawa, Yoshinori
Nakamura, Hideo
To ascertain roles of the two basic nitrogen atoms in 1-substituted 4- [2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (1) in the expression of opioid agonist and antagonist activities, a methine group (CH) was isosterically substituted for nitr
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Doi:10.1016/S0020-1693(99)00323-0
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