Roles of two basic nitrogen atoms in 1-substituted 4-(1,2- diphenylethyl)piperazine derivatives in production of opioid agonist and antagonist activities

DOI: 10.1248/cpb.47.1790

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1790 - 1793 (1999)

Update date:2022-07-30

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Authors:

Natsuka, Kagayaki

Nishikawa, Yoshinori

Nakamura, Hideo

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Article abstract of DOI:10.1248/cpb.47.1790

To ascertain roles of the two basic nitrogen atoms in 1-substituted 4- [2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (1) in the expression of opioid agonist and antagonist activities, a methine group (CH) was isosterically substituted for nitr

Full text of DOI:10.1248/cpb.47.1790

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