Synthesis of a new dual metalloprotease inhibitor. II. Stereoselective synthesis of peptidomimetic [5.7]-bicyclic compounds

DOI: 10.1248/cpb.47.1532

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1532 - 1537 (1999)

Update date:2022-07-31

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Authors:

Akasaka, Kozo

Komatsu, Yuki

Tagami, Katsuya

Shimizu, Toshikazu

Shimomura, Naoyuki

Naka, Hiroshi

Hayashi, Kenji

Negi, Shigeto

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Article abstract of DOI:10.1248/cpb.47.1532

An efficient synthetic process for the key intermediate of a new peptidomimetic dual metalloprotease inhibitor, ER-40133, was developed. (5R)- Methyl-6-oxopipecolic acid ester (3a), prepared from L-α,-aminoadipic acid, was chemoselectively reduced to the

Full text of DOI:10.1248/cpb.47.1532

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Product name:diphenylmethyl (2S,5S,6RS)-N-benzyloxycarbonyl-6-hydroxy-5-methyl-2-pipecolic acid

Cas No:259151-28-5

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