A scalable and expedient route to 1-Aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy

Article abstract of DOI:10.1021/ol400493x

A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl₄-catalyzed cycloisomerization. Not only does this method allow access to these func