Asymmetric synthesis of bicyclic ketones having an angular substituent via Ti(II) alkoxide-mediated tandem cyclization of trisubstituted olefinic substrates

DOI: 10.1021/ol9904038

Source and publish data:

Organic Letters p. 381 - 383 (2000)

Update date:2022-08-04

Topics:

Authors:

Urabe, Hirokazu

Hideura, Daigaku

Sato, Fumie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ol9904038

(Formula Presentation) Angularly substituted, optically active bicyclic ketones of up to 94% ee were prepared by the Ti(II) alkoxide-mediated tandem cyclization of open-chain substrates, that is, 8-phenylmenthyl enynoates having a trisubstituted double bond.

Full text of DOI:10.1021/ol9904038

Products guided by the article

Product name:(-)-2,5-dimethyl-1-bicyclo[3.3.0]octen-3-one

Cas No:259733-38-5

R&D Labs maybe for 259733-38-5

Chameleon Specialty Chemicals

Contact:+44 7958 511245

Address:PO Box 469, Manchester, UK
AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Hubei Xiangxi Chemical Industry Co.,Ltd

Contact:+86-710-3454830

Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China
Dongtai Xinyuan Chemical Co., Ltd.

Contact:+86-21-56733000

Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai

Relevant to this article

Doi:10.1021/jo01107a006
(1956)
Intramolecular asymmetric Pummerer reactions as a key step in the synthesis of bicyclic precursors of anthracyclinones

Doi:10.1016/S0040-4039(99)02025-0
(2000)
Doi:10.1021/jo01264a009
(1969)
Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction

Doi:10.1021/jm300969t
(2012)
Double N,B-Type Bidentate Boryl Ligands Enabling a Highly Active Iridium Catalyst for C-H Borylation

Doi:10.1021/jacs.5b05252
(2015)
Doi:10.1016/S0040-4020(01)97869-X
(1970)

Article Doi