Synthesis of novel C7-aryl substituted pyrrolo[2,i- c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling

DOI: 10.1016/S0960-894X(97)10083-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3017 - 3018 (1998)

Update date:2022-08-05

Topics:

Authors:

Guiotto, Andrea

Howard, Philip W.

Giovanni Baraldi, Pier

Thurston, David E.

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Article abstract of DOI:10.1016/S0960-894X(97)10083-X

Novel C7-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized via Suzuki coupling between a 7-Iodo N10-Troc-protected PBD carbinolamine and commercially available boronic acids.

Full text of DOI:10.1016/S0960-894X(97)10083-X

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Product name:(11S,11aS)-7-(3'-nitro)phenyl-10-N-(2'',2'',2''-trichloroethoxycarbonyl)-1,2,3,10,11,11a-hexahydo-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one

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