Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation

DOI: 10.1021/jm00075a015

Source and publish data:

Journal of Medicinal Chemistry p. 3606 - 3610 (1993)

Update date:2022-07-30

Topics:

Authors:

Ding Ding

Silverman

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Article abstract of DOI:10.1021/jm00075a015

3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-[(methylamino)methyl]-2- oxazolidinone (1) is a secondary amine known to be a potent time-dependent irreversible inactivator of monoamine oxidase B (MAO-B). The primary amine analogues of derivatives of 1, as well a

Full text of DOI:10.1021/jm00075a015

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