Electrochemical methylation of a chelate anionic NiI complex with methylcobaloxime. Partial modeling of the action mechanism of the active center of acetyl-CoA synthase

Article abstract of DOI:10.1007/BF02499065

Electrochemically generated anions of Co and Ni chelate complexes can be alkylated with BuⁿBr, BuⁿI, and (dmgH)₂CoMe (dmgH is the dimethylglyoximate anion). Unlike the anionic Co complexes, the anionic Ni complex cannot be alkylated with BuⁿBr; however, it reacts with stronger alkylating agents (BuⁿI and (dmgH)₂CoMe). It is assumed that the electrochemical alkylation of the Ni complex with (dmgH)₂CoMe can serve as a model for alkylation occurring in biological synthesis of acetyl coenzyme A. Reactions of some Co chelate anions with BuⁿI can proceed via the reduction of the latter.