Bioorganic and Medicinal Chemistry Letters p. 771 - 773 (2000)
Update date:2022-07-30
Topics:
Rondeau, Dany
Gill, Patrice
Chan, Monique
Curry, Kenneth
Lubell, William D.
Seven Δ3-4-arylkainoids possessing various 4-position aromatic and heteroaromatic groups were synthesized and their apparent affinities were measured in order to explore the influences of 4-position electron density and stereochemistry on receptor affinity and specificity. Kainoids 1a-f were shown to be selective agonists at the NMDA receptor and the electron rich furanyl and thienyl analogues exhibited the highest affinities. Naphthylkainoid 1g proved to be a nonselective antagonist at the iGluRs. (C) 2000 Elsevier Science Ltd. All rights reserved.
View MoreContact:86-28-61993785
Address:No.70-13-21, North Section, Erhuan
Shanghai Norky Pharmaceutical Co., LTD.
website:http://www.norkypharm.com
Contact:86-21-61075300
Address:1165 Jiangning Road, Office 1502, Shanghai, China
Xiamen Huasing Chemicals Co.Ltd.
Contact:0086-592-6228397
Address:NO.24, Xinglin North 2nd Road,Jimei district
Contact:+86-519-86339586,13584329896
Address:Changzhou Scientific and Education Park
HaiNan Periwinkle Pharmaceutical Co.,Ltd.
website:http://www.cchpharm.com/en/index.html
Contact:020-82208978
Address:Gongye road,Wuzhishan city,HaiNan province
Doi:10.1016/j.tet.2017.05.010
(2017)Doi:10.1002/oms.1210030309
(1970)Doi:10.1021/jm0000923
(2000)Doi:10.1039/b810352f
(2008)Doi:10.1016/S0040-4039(00)85251-X
(1986)Doi:10.1002/1099-0690(200108)2001:16<3175::AID-EJOC3175>3.0.CO;2-4
(2001)