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(16) 1,1-BPSE was stable when maintained alone in toluene at 150
°C, 24 h. Therefore, a transformation of 1,1-BPSE into 1,2-BPSE was
discarded.
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(18) The thermodynamic control was discarded by heating pure
endo-2,5-cis-6aa at 150 °C during 20 h. No traces of the most stable
compound endo-2,5-trans-6aa were observed, and endo-2,5-cis-6aa
remained unaltered.
(19) The reaction with NMM was performed first in order to
optimize the synthetic route for the preparation of the most interesting
compound 9ai. In fact, this N-methylated family stopped in compound
8aa.
E
Org. Lett. XXXX, XXX, XXX−XXX