Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin

DOI: 10.1021/ja003292c

Source and publish data:

Journal of the American Chemical Society p. 870 - 874 (2001)

Update date:2022-08-03

Topics: Solid-phase synthesis Yield NMR spectroscopy Bioassay HPLC Chiral center Total synthesis Mass spectrometry (MS) Enantioselective synthesis Deprotection Antibacterial activity Protecting group Retrosynthetic analysis Mycobacterium tuberculosis Peptide Coupling Semisynthetic Stereochemical Elucidation

Authors:

Boojamra

Lemoine Lemoine

Lee Lee

Leger Leger

Stein Stein

Vernier Vernier

Magon Magon

Lomovskaya

Martin Martin

Chamberland

Lee Lee

Hecker Hecker

Lee Lee

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Article abstract of DOI:10.1021/ja003292c

Hydrogenation of the C(4′) exocyclic olefin of the pacidamycins has been shown to produce a series of semisynthetic compounds, the dihydropacidamycins, with antimicrobial activity similar to that of the natural products. Elucidation of stereochemistry in

Full text of DOI:10.1021/ja003292c

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Article Doi

Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin

DOI: 10.1021/ja003292c

Source and publish data:

Authors:

Article abstract of DOI:10.1021/ja003292c

Full text of DOI:10.1021/ja003292c

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