Journal of Organic Chemistry p. 4893 - 4900 (1999)
Update date:2022-08-03
Topics:
Hanessian, Stephen
Cantin, Louis-David
Andreotti, Daniele
We report the total synthesis of the cytotoxic agent (-)-anthoplalone and the determination of its absolute stereochemistry. The cyclopropane moiety was prepared using a nonracemic bicyclic chloroallyl phosphonamide anion addition to tert-butyl 3,3-dimethyl acrylate. Several pathways were studied to secure the E-trisubstituted olefin of the left part of the molecule.
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Doi:10.1021/ol005962p
(2000)Doi:10.1021/ol000129d
(2000)Doi:10.1016/S0960-894X(99)00367-4
(1999)Doi:10.1021/ja01277a040
()Doi:10.1021/ol9910058
(1999)Doi:10.1016/S0022-328X(99)00277-6
(1999)
