Synthesis and characterization of Bis-quinazolines from linear tetra-amines involving 2-(aminomethyl)benzenamine with aldehydes

Article abstract of DOI:10.1002/jhet.807

Three tetra-amine compounds 2-((2-(2-aminobenzylamino)ethylamino)methyl) benzenamine (L₁), 2-((3-(2-aminobenzylamino)propylamino)methyl) benzenamine (L₂), and 2-((4-(2-aminobenzylamino)butylamino)methyl) benzenamine (L₃) were synthesized and then their reaction with 2-hydroxybenzaldehyde, 2-nitrobenzaldehyde, and 2-hydroxy-3-methoxybenzaldehyde were investigated. Treatment of L₁, L₂, and L₃ with the former aldehydes gave derivatives of quinazolines in a good yield. The products have been studied with IR, ¹H NMR, ¹³C NMR, COSY, HMQC, and microanalysis.