Synlett p. 41 - 44 (2004)
Update date:2022-08-03
Topics:
Rikimaru, Kentaro
Yanagisawa, Arata
Kan, Toshiyuki
Fukuyama, Tohru
The Ugi four-component condensation (4CC) reaction with the carbonate-type isonitrile 9 proceeded smoothly, and subsequent base treatment of the Ugi products 10 provided the N-acyloxazolidinones 11 in high yield. The N-acyloxazolidinones derivatives can be reacted with several hetero-nucleophiles, namely, reaction of 11 with thiolates gave thiol ester derivatives 16 efficiently.
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(2004)
