Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 6. Synthesis of a key intermediate via a highly efficient macrolactonization of a computer-aid designed seco-acid

DOI: 10.1248/cpb.48.855

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 855 - 860 (2000)

Update date:2022-08-03

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Authors:

Matsushima, Tomohiro

Nakajima, Noriyuki

Zheng, Bao-Zhong

Yonemitsu, Osamu

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Article abstract of DOI:10.1248/cpb.48.855

A stereoselective synthesis is described of the 18-membered lactone (2) via an efficient macrolactonization of the conformation-controlled seco-acid (3); this was designed with the aid of molecular mechanics (MM)-calculation and synthesized by coupling between the C1 - C12 (4) and C13 - C23 (5) fragments.

Full text of DOI:10.1248/cpb.48.855

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