Chemical and Pharmaceutical Bulletin p. 982 - 990 (2000)
Update date:2022-08-05
Topics:
Eto, Hiromichi
Kaneko, Yasushi
Sakamoto, Takao
New 1,2,4-triazoles (1) having a difluoro(heteroaryl)methyl moiety were designed and synthesized via 1-aryl-2,2-difluoro-2- (heteroaryl)ethanones (2), which were prepared by two routes starting from the reaction of ethyl 2,2- difluoro(heteroaryl)acetate with phenyllithiums (Route A) and from the reaction of chlorodifluoro(heteroaryl)methane with benzaldehydes (Route B). The compounds 1 except for 1g show antifungal activities against yeasts and filamentous fungi in vitro, especially (+)-If have equal or superior activities compared to those of itraconazole.
View MoreSICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
Chengdu Boon Stream Chemical Industry Co.,Ltd.
Contact:+86-28-83156758
Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
ningbo easun bio-tech co., ltd
website:http://www.easunbiotech.com
Contact:+8657462089878
Address:Ru Lake Road No. 23, Simen Town , Yuyao City,Zhejiang province
Onlychem (Jinan)Biotech Co.,Ltd
Contact:86-531-83175885
Address:No. 44, Honglou South Road, Jinan,China
Jinan Trio PharmaTech Co., Ltd
Contact:86-531-88811783；+(0)13153010282
Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
Doi:10.1246/bcsj.20150316
(2016)Doi:10.1016/S0040-4020(01)83145-8
(1973)Doi:10.1016/S0957-4166(00)00224-X
(2000)Doi:10.1002/(SICI)1099-0690(200003)2000:6<1007::AID-EJOC1007>3.0.CO;2-I
(2000)Doi:10.1016/S0223-5234(00)00152-5
(2000)Doi:10.1021/jo00815a001
(1971)
