Asymmetric synthesis of bicyclic α-amino acids by a Diels-Alder reaction to a new chiral α,β-didehydroalanine derivative

Article abstract of DOI:10.1016/S0957-4166(99)00061-0

A new chiral cyclic α,β-didehydroalanine derivative, (6S)-6-isopropyl- 3-methylene-5-phenyl-3,6-dihydro-2H-1,4-oxazin-2-one, has been prepared by in situ aminomethylation-elimination of a chiral glycine-derived precursor. This oxazin-2-one acts as a react