New achievements in the field of intramolecular phenolic coupling reactions, using hypervalent (III) iodine reagent: Synthesis of galanthamine

Article abstract of DOI:10.1080/00397910008087434

Our investigations on the Oxidative possibilities of the hypervalent iodine(III) reagent established that phenyliodine(III)bis(trifluoroacctate (PIFA) can provide one-pot contiguous coupling-cyclization reaction giving a product with narwedine skeleton, when used in a phenolic coupling reaction of p'-bromonorbelladine derivatives. A suitably selected precursor gave up to 60% yield of the coupled product.

Full text of DOI:10.1080/00397910008087434

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Synthetic Communications: An
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New Achievements in the
Field of Intramolecular
Phenolic Coupling Reactions,
Using Hypervalent (III)
Iodine Reagent: Synthesis of
Galanthamine
Dikran Krikorian a , Velichko Tarpanov a , Stoyan
Parushev a & Pepa Mechkarova a
a Institute of Organic Chemistry with Centre of
Phytochemistry, Bulgarian Academy of Sciences ,
1113, Sofia, Bulgaria E-mail:
Published online: 04 Dec 2007.
To cite this article: Dikran Krikorian , Velichko Tarpanov , Stoyan Parushev & Pepa
Mechkarova (2000) New Achievements in the Field of Intramolecular Phenolic Coupling
Reactions, Using Hypervalent (III) Iodine Reagent: Synthesis of Galanthamine,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 30:16, 2833-2846, DOI: 10.1080/00397910008087434
To link to this article: http://dx.doi.org/10.1080/00397910008087434
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