Synthesis and antibacterial activity of 4-ureido trinems

Article abstract of DOI:10.1016/S0960-894X(96)00515-X

This article describes studies carried out on the synthesis and biological activity of 4-ureido trinems 1 obtained by the condensation of various isocyanates and the intermediate 6. Among others, 4-N-methyl-N'-alkyl ureido trinems showed a promising antimicrobial activity against Gram-negative bacteria.