Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs

DOI: 10.1248/cpb.48.1270

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Chemical and Pharmaceutical Bulletin p. 1270 - 1280 (2000)

Update date:2022-08-03

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Authors:

Itoh, Fumio

Yoshioka, Yoshio

Yukishige, Koichi

Yoshida, Sei

Ootsu, Koichiro

Akimoto, Hiroshi

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Article abstract of DOI:10.1248/cpb.48.1270

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,

Full text of DOI:10.1248/cpb.48.1270

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Product name:ethyl N^α-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-N^δ-benzyoxycarbonyl-L-ornithinate

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