Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs

DOI: 10.1248/cpb.48.1270

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1270 - 1280 (2000)

Update date:2022-08-03

Topics:

Authors:

Itoh, Fumio

Yoshioka, Yoshio

Yukishige, Koichi

Yoshida, Sei

Ootsu, Koichiro

Akimoto, Hiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.48.1270

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,

Full text of DOI:10.1248/cpb.48.1270

NII-Electronic Library Service

Products guided by the article

Product name:ethyl N^α-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-N^δ-benzyoxycarbonyl-L-ornithinate

Cas No:303957-90-6

R&D Labs maybe for 303957-90-6

KODI CHEMICAL CO., LTD

Contact:021

Address:Pudong
Huzhou City Linghu Xinwang Chemical Co.,Ltd.

Contact:86-572-3948695/3945236

Address:huzhou
KindChem Co.,Ltd,

Contact:+86-25-85281586

Address:13F,Bld2#,South of Longpan Road
Hangzhou Donglou Bio-nutrient Co., Ltd.

Contact:+86-571-82225795,13967112289

Address:Louta Town, Xiaoshan,Hangzhou,Zhejiang
Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

website:http://www.bjgreenchem.com/

Contact:+86-427-6515887

Address:301,302, 3rd Floor, Building C-7, Dongsheng Science Park, Northern Territory, Zhongguancun, No. 66, Xixiaokou Road, Haidian District, Beijing

Relevant to this article

Doi:10.1016/S0040-4020(01)93150-3
(1970)
Doi:10.1021/jm00283a031
(1971)
Selective catalytic hydrogenations and hydrogenolyses, IV: Preparation of 1-benzylisoquinolines

Doi:10.1002/ardp.19853180603
(1985)
Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors

Doi:10.1016/j.bmc.2016.10.002
(2016)
Catalytic asymmetric synthesis of (S)-oxybutynin and a versatile intermediate for antimuscarinic agents

Doi:10.1016/j.tet.2004.08.081
(2004)
Convenient synthesis of more complex 2-substituted 4(3H)-quinazolinones via lithiation of 2-alkyl-4(3H)-quinazolinones

Doi:10.1135/cccc19990515
(1999)

Article Doi