Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors

DOI: 10.1016/j.bmc.2016.10.002

Source and publish data:

Bioorganic and Medicinal Chemistry p. 6206 - 6214 (2016)

Update date:2022-08-03

Topics:

Authors:

Zhang, Jiankang

Gao, Lixin

Xi, Jianjun

Sheng, Li

Zhao, Yanmei

Xu, Lei Xu, Lei

Shao, Yidan

Liu, Shourong

Zhuang, Rangxiao

Zhou, Yubo

Li, Jia Li, Jia

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Article abstract of DOI:10.1016/j.bmc.2016.10.002

A series of novel non-covalent piperidine-containing dipeptidyl derivatives were designed, synthesized and evaluated as proteasome inhibitors. All target compounds were tested for their proteasome chymotrypsin-like inhibitory activities, and selected deri

Full text of DOI:10.1016/j.bmc.2016.10.002

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Product name:tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

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