Highly efficient synthesis of 3,4-dihydro-2(1H)-quinolinone derivatives under microwave heating

Article abstract of DOI:10.3987/COM-12-12489

A sequential three-component reaction of aromatic aldehydes with aromatic amine, and Meldrum's acid in EtOH under microwave irradiation has been developed. In this one-pot reaction, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized with high chemical yields. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.