Benzo[c]quinolizin-3-ones: A novel class of potent and selective nonsteroidal inhibitors of human steroid 5α-reductase 1

DOI: 10.1021/jm000945r

Source and publish data:

Journal of Medicinal Chemistry p. 3718 - 3735 (2000)

Update date:2022-09-26

Topics: Inhibitors Chemical Synthesis Structure-Activity Relationship (SAR) Studies Potent Selective Enzyme assay Nonsteroidal Cell-based assay

Authors:

Guarna Guarna

Machetti

Occhiato

Scarpi Scarpi

Comerci, Alessandra

Danza, Giovanna

Mancina, Rosa

Serio, Mario

Hardy, Kimber

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm000945r

The synthesis and biological evaluation of a series of novel, selective inhibitors of isoenzyme 1 of human 5α-reductase (5αR) (EC 1.3.99.5) are reported. The inhibitors are 4aH- (19-29) or 1H-tetrahydrobenzo[c]quinolizin-3-ones (35-47) bearing at position

Full text of DOI:10.1021/jm000945r

Products guided by the article

Product name:3-chloro-butyric acid-(4-chloro-anilide)

Cas No:307335-67-7

R&D Labs maybe for 307335-67-7

Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Foreschem Co., Ltd

Contact:+86-533-3112891

Address:zibo
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.

Contact:86-532-88250866

Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China

Relevant to this article

Novel α-amino acid-based hydroxamic acid ligands for vanadium-catalyzed asymmetric epoxidation of allylic alcohols [2]

Doi:10.1021/ja002602o
(2000)
Electron Paramagnetic Resonance and ENDOR Study of Semiquinones in Reversed Micelles

Doi:10.1039/ft9908603191
(1990)
Scope and limitation of the [1,2]-phenylsulfanyl (PhS) migration in the asymmetric synthesis of tetrahydrofurans and tetrahydropyrans from common triol precursors

Doi:10.1039/b005336h
(2000)
New synthons for the preparation of arylimidazolines and tetrahydropyrimidine analogues

Doi:10.1055/s-2007-966047
(2007)
Total synthesis of (-)-penitrem D [15]

Doi:10.1021/ja0030820
(2000)
PEG₄₀₀-enhanced synthesis of gem-dichloroaziridines and gem-dichlorocyclopropanes via in situ generated dichlorocarbene

Doi:10.1039/c3ra43307b
(2013)

Article Doi