Benzo[c]quinolizin-3-ones: A novel class of potent and selective nonsteroidal inhibitors of human steroid 5α-reductase 1

DOI: 10.1021/jm000945r

Source and publish data:

Journal of Medicinal Chemistry p. 3718 - 3735 (2000)

Update date:2022-09-26

Topics: Inhibitors Chemical Synthesis Structure-Activity Relationship (SAR) Studies Potent Selective Enzyme assay Nonsteroidal Cell-based assay

Authors:

Guarna Guarna

Machetti

Occhiato

Scarpi Scarpi

Comerci, Alessandra

Danza, Giovanna

Mancina, Rosa

Serio, Mario

Hardy, Kimber

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Article abstract of DOI:10.1021/jm000945r

The synthesis and biological evaluation of a series of novel, selective inhibitors of isoenzyme 1 of human 5α-reductase (5αR) (EC 1.3.99.5) are reported. The inhibitors are 4aH- (19-29) or 1H-tetrahydrobenzo[c]quinolizin-3-ones (35-47) bearing at position

Full text of DOI:10.1021/jm000945r

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