Once the candidates are selected, chemical synthesis is carried out to create the designed hybrid compounds. This may involve the conjugation of the etoposide analog and the nitrogen mustard component, while ensuring that the resulting molecule retains the desired binding properties.
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
4-(3-AMINOPROP-1-YL)AMINOQUINOLINE
N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-D-lysine
1-(4-amino-3-n-butoxyphenyl)ethanone
(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
4-fluoro-2-(methoxycarbonylmethyl)benzenesulfonamide
4-nitro-3-(3-bromophenylamino)pyridine N-oxide
dibenzyl N-(phosphonoacetyl)aspartate
3-(anilinocarbonyl)-2-pyrazinecarboxylic acid
1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
C15H10BrClO2
C9H10NS2(1-)*K(1+)
6-(4-methoxybenzylamino)-9-(tetrahydropyran-2-yl)-9H-purine
Boc-Pro-Lys(Z)-Pro-OCH3
)
Carbamic acid, [2-oxo-2-[(2-phenylethyl)amino]ethyl]-, phenylmethyl ester
tert-butyl (S)-3-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
bis(benzonitrile)palladium(II) dichloride
2-Propanol, 1-amino-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (S)-
Silica gel
{3-[(4-benzoylpiperazin-1-yl)(oxo)acetyl]-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
7-bromo-N-[(1-oxyl-4-bromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
E-3-(5-benzylidene-2-oxo-5,6-dihydro-2H-pyran-3-yl)propionic acid methyl ester
anisaldehyde
Triethylamine
Hexanoic acid, 4-oxo-6-[[(phenylmethoxy)carbonyl]amino]-
{(S)-3-Benzyloxy-1-[(2S,6R)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-propoxy}-tert-butyl-diphenyl-silane
Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
2’-(4-nitrophenoxycarbonyl)paclitaxel
(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
2,3-dibromo-1-(bromomethyl)-4,5-dimethoxybenzene
((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate
1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
tert-butyl 4-(4-cyanobenzylcarbamoyl)piperidine-1-carboxylate
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
(((15-bromopentadecyl)oxy)methyl)benzene
2-(4-nitrophenyl)-4-hydroxythieno[3,2-d]pyrimidine
methyl 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-β-D-galactopyranoside
1-(4-chloro-3-methylphenyl)heptan-1-one
Benzeneacetonitrile, a-[bis[4-[2-(diethylamino)ethoxy]phenyl]methylene]-
4-methyl-2-oxo-2H-chromen-7-yl N-phenylglycinate
(E)-2-(4-fluorostyryl)-3,4,5-trimethoxybenzaldehyde
(2E)-2-(2,2-diphenylethylidene)hydrazinecarboxamide
C22H19N3O5S
INDOLE-3-CARBOXALDEHYDE
Barbituric acid
Z-phenyl-2-azo-6-acetyl-morphine
CODEINE
sodium hydroxide
(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate
Silica gel
1-(cyclohexylmethyl)-4-iodo-1H-pyrazole
1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
Fumaric acid
