Synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines via a Pictet-Spengler cyclisation

Article abstract of DOI:10.1002/jhet.5570370417

The synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines (6a,b,c) was achieved via a Pictet-Spengler cyclization of an activated amino group derivatized in a carbamate form. The obtained compounds have been designed as potential serotonin analo