Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase

DOI: 10.1016/S0960-894X(99)00425-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2549 - 2554 (1999)

Update date:2022-09-26

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Authors:

Greenlee, Mark L.

Laub, Joanne B.

Balkovec, James M.

Hammond, Milton L.

Hammond, Gail G.

Pompliano, David L.

Epstein-Toney, Jeffrey H.

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Article abstract of DOI:10.1016/S0960-894X(99)00425-4

Potent thioester and thiol inhibitors of IMP-1 metallo-β-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.

Full text of DOI:10.1016/S0960-894X(99)00425-4

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