Synthesis and Bioactivity of a New Class of Rigid Glutamate Analogues. Modulators of the N-Methyl-D-aspartate Receptor

DOI: 10.1021/jm00168a007

Source and publish data:

Journal of Medicinal Chemistry p. 1561 - 1571 (1990)

Update date:2022-08-05

Topics:

Authors:

Kozikowski, Alan P.

Tueckmantel, Werner

Reynolds, Ian J.

Wroblewski, Jarda T.

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Article abstract of DOI:10.1021/jm00168a007

A variety of derivatives of azetidine-2,4-dicarboxylic acid were synthesized and examined for their ability to stimulate 45Ca²⁺ uptake in cultures of cerebellar granule cells.Of the compounds tested, the cis-azetidine-2,4-dicarboxylic acid (10f

Full text of DOI:10.1021/jm00168a007

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