Synthesis of tritium labeled (±)-1-[2-(triphenylmethoxy)ethyl]-3-piperidinecarboxylic acid: A possible compound to determine the efficacy of potential GABA transporter substances in vitro

Article abstract of DOI:10.1002/1099-1344(20001015)43:11<1127::AID-JLCR399>3.0.CO;2-9

(±)- 1-[2-(Triphenyl[³H]methoxy)ethyl]-3-piperidinecarboxylic acid ([³H]SNAP-5114) with a specific activity of 40 Ci/mmol was prepared in a two step synthesis starting from ethyl (2-(4-hydroxyphenyl)bis(4-methoxyphenyl)methoxy)-ethyl)piperidine-3-carboxyla te and [³H]methyliodide with subsequent hydrolysis of the resulting ester with lithium hydroxide to yield the desired [³H]SNAP-5114. (C) 2000 John Wiley and Sons, Ltd.