New 2H-chromene-3-carboxamide derivatives: Design, synthesis and use as inhibitors of hMAO

DOI: 10.1016/j.ejmech.2014.04.060

Source and publish data:

European Journal of Medicinal Chemistry p. 278 - 284 (2014)

Update date:2022-07-29

Topics:

Authors:

Pan, Zhi-Xiang

He, Xu He, Xu

Chen, Yan-Yan

Tang, Wen-Jian

Shi, Jing-Bo

Tang, Yu-Lan

Song, Bao-An

Li, Jun Li, Jun

Liu, Xin-Hua

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Article abstract of DOI:10.1016/j.ejmech.2014.04.060

A series new 2H-chromene-3-carboxamide derivatives 4a-4t were synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. Among them, compound 4d (IC₅₀ = 0.93 μM, IC_{50 iproniazid} = 7.80 μM) showed the most ac

Full text of DOI:10.1016/j.ejmech.2014.04.060

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