Rhodium-catalyzed enantioselective Michael addition of (1-cyanoethyl)phosphonate: Synthesis of optically active phosphonic acid derivatives with phosphorus-substituted quaternary asymmetric carbon center

Article abstract of DOI:10.1246/bcsj.73.2559

Asymmetric Michael addition of diethyl (1-cyanoethyl)phosphonate with vinyl ketones or acrylaldehyde in the presence of 0.01 molar amount of a rhodium catalyst prepared in situ from Rh(acac)(CO)₂ and a trans-chelating chiral diphosphine ligand