Bioorganic and Medicinal Chemistry Letters p. 1311 - 1316 (1999)
Update date:2022-08-05
Topics:
Williams, Peter D.
Bock, Mark G.
Evans, Ben E.
Freidinger, Roger M.
Gallicchio, Steven N.
Guidotti, Maribeth T.
Jacobson, Marlene A.
Michelle S, Kuo
Levy, Michelle R.
Edward V, Lis
Michelson, Stuart R.
Pawluczyk, Joseph M.
Perlow, Debra S.
Pettibone, Douglas J.
Quigley, Amy G.
Reiss, Duane R.
Salvatore, Christopher
Stauffer, Kenneth J.
Woyden, Carla J.
Structure-activity studies on the oxytocin antagonist 1 (L-371,257; K(i) = 9.3 nM) have led to the identification of a related series of compounds containing an ortho-trifluoroethoxyphenylacetyl core which are orally bioavailable and have significantly improved potency in vitro and in vivo, e.g., compound 8 (L-374,943; K(i) = 1.4 nM).
View MoreKA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
Xinji City Taida Sinopec Co., Ltd.
Contact:0086-311-85341278
Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Rugao Jinling Chemical Co., Ltd.(expird)
Contact:0086-513-68005586
Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Beijing Mesochem Technology Co.,LTD
website:http://www.mesochem.com
Contact:0086-10-57862036
Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Doi:10.1021/ja00271a033
(1986)Doi:10.1002/cjoc.201090280
(2010)Doi:10.1055/s-0035-1562528
(2016)Doi:10.1007/BF00869027
()Doi:10.1021/jo00966a004
(1972)Doi:10.1007/BF00849353
()
