
Chemical and Pharmaceutical Bulletin p. 1702 - 1710 (2000)
Update date:2022-08-02
Topics: Synthesis Column chromatography NMR spectroscopy Fluorescence emission Thin-layer chromatography (TLC) Azole UV-Vis Spectroscopy Fluorescence Spectroscopy Coumarin Stokes Shift Quantum Yield Solvatochromism π-conjugation Yield calculation Solvent Optimization Melting Point Determination
Takechi
Oda
Nishizono
Oda
Machida
In order to find a highly sensitive fluorophore, 3-azolyl-7-diethylaminocoumarin derivatives were synthesized. Both the absorption and fluorescence maxima of the coumarin-thiazole compounds showed red shifts with increases of the molar absorptivities and fluorescence intensities, in comparison with those of the corresponding coumarin-oxazole compounds. Among them, 3-(5-ethoxycarbonyl-1,3-thiazol-2-yl)-7-diethylamino-2H-chromen-2-one (3e) was one of the most promising candidates as a fluorophore accessible for analytical purposes in the fields of analytical and biological chemistry.
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Doi:10.1039/c3gc41218k
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