Synthesis of sultam derivatives with expected biological activity. 15

Article abstract of DOI:10.3390/50600816

4-(Trihydro-2H-1,2-thiazole-1,1-dioxide-2-yl)benzophenone (1), 4-(3,5-dimethyl-1′,2′-thiazine-1′,1′-dioxide-2-yl) benzophenone (2), and 4-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl) benzophenone (6) were obtained from 4-aminobenzophenone and the appropriate reagents. Isomeric (E-) and (Z-) 2-Ethoxycarbonyl-4-phenyl-4-(4-tetrahydro-1,2- thiazine-1,1-dioxide-2-yl)phenyl-3-butenoic acids (11 and 12) and 2-carboxy-4(N-phenyl-thiocarbamoyl)-1-phenyl-6-(tetrahydro-2H-1,2-thiazine-1, 1-dioxide-2-yl)naphthalene (16) were also synthesized.

Full text of DOI:10.3390/50600816

Molecules 2000, 5, 816-825
molecules
ISSN 1420-3049
http://www.mdpi.org
Synthesis of Sultam Derivatives with Expected Biological
Activity. 15†
S.H. Doss1, V.B. Baghos2, A.O. Abdelhamid2* and M.M.A. Halim1
1National Research Center, Giza, Egypt
2Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
E-mail: Abdou@main-scc.cairo.eun.eg
†
For Part XIV, see reference 2a
Received: 10 February 2000 / Accepted: 30 May 2000 / Published: 10 June 2000
Abstract: 4-(Trihydro-2H-1,2-thiazole-1,1-dioxide-2-yl)benzophenone (1), 4-(3,5-dimethyl-
1`,2`-thiazine-1`,1`-dioxide-2-yl)benzophenone (2), and 4-(tetrahydro-2H-1,2-thiazine-1,1-
dioxide-2-yl)benzophenone (6) were obtained from 4-aminobenzophenone and the appro-
priate reagents. Isomeric (E-) and (Z-) 2-Ethoxycarbonyl-4-phenyl-4-(4-tetrahydro-1,2-
thiazine-1,1-dioxide-2-yl)phenyl-3-butenoic acids (11 and 12) and 2-carboxy-4(N-phenyl-
thiocarbamoyl)-1-phenyl-6-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)naphthalene (16)
were also synthesized.
Keywords: Sultam derivatives.
Introduction
Many sultam derivatives were found to possess valuable therapeutic properties such as; e.g., anti-
tumor activity [1a] and anticonvulsive activity [1b,c]. In conjunction with our current research on sul-
tam [2a] and on the Stobbe condensation [2b], we attempted to synthesize compounds expected to pos-
sess biological activity.
© 2000 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.

817
Molecules 2000, 5
Results and Discussion
4-Aminobenzophenone [3] was condensed with oxathiolan-2,2-dioxide, 4,6-dimethyl-1,2-oxathiin-
2,2-dioxide, cyanoacetohydrazide and phenyl isothiocyanate to give the corresponding derivatives 1-4,
respectively. 4-(tetrahydro-2H-1,2-thiazin-1,1-dioxide-2-yl) benzophenone (6) was also prepared (cf.
Scheme 1). The UV spectra of the sultamyl derivatives exhibited maximum absorption band at l max
*
235-254 nm (EtOH) assigned to the vibrational structure of the sultamyl group (n-p ) transition [4].
Additional bands at l max 305-335 nm (EtOH) were present, also characteristic of the sultamyl group,
but which were absent from the spectrum of the thiourea derivative.
CH3
N
COPh
H3C
SO2
2
NNHCOCH2CN
C-Ph
H2N
COPh
H2N
N
COPh
SO2
3
1
SO2
NHSO2(CH2)4Cl
N
PhNHCSHN
COPh
4
COPh
5
COPh
6
Scheme 1.
Compound 6 reacted with cyanoacetohydrazide to give 4-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-
2-yl)benzophenonecyanoacetohydrazone (7). The structure of the latter product was elucidated on the
basis of its elemental analysis and spectral data (cf. Experimental). Sultam derivatives 8-10 were ob-
tained by the reaction of compound 7 with benzenediazonium chloride, benzaldehyde and salicylalde-
hyde, respectively (cf. Scheme 2). Structures 8-10 were confirmed on the basis of elemental analyses
and spectral data (cf. Experimental).
Ketone 6 was condensed with diethyl succinate to give an oily half-ester (82%). The (E-) and (Z-)
3-ethoxycarbonyl-4-phenyl-4-(4-tetrahydro-1,2-thiazine-1,1-dioxide-2-yl)-3-butenoic acids were sepa-
rated by fractional crystallization; the (E-) isomer was predominant. The relative ratio was estimated
by the application of the spectrophotometric method [5], the ratio was almost the same as the ratio ob-
tained by fractional crystallization (6:1).

818
Molecules 2000, 5
SO2
SO2
SO2
N
N
N
COPh
PhC=NNHCOCH2CN
7
Ph
6
NNHCOCCN
NNHPh
8
SO2
N
SO2
N
O
Ph
NNHC
O
O
Ph
NNHCOCCN
9
CHPh
10
Scheme 2.
The relative proportion of the two hemiesters obtained is determined by polar non-bonded interac-
tions existing between the groups attached the carbonyl of the ketone and the carbanion. The predomi-
nance of the (E-) isomer is most likely probably due to the polar factor since repulsion between Ph and
-COOR is expected to be less significant than that between Ar and –COOR. The polar factor i.e., re-
pulsion between Ph and COOEt and between Ar and COOEt probably plays the more important role
(See Figure 1).
+
OBu
-
+
-
OBu
Ar
ph
H
ph
Ar
H
O
O
O
O
OEt
OEt
O
O
(A)
(B)
O
2 S
Ar =
N
Figure 1.
The conjugation of the lone pair of N in the sultam ring will increase electron density in the Ar
group. Thus the (E-) Ar/-COOR configuration is expected to be predominant, as found experimentally.
Evidence for the (E-) configuration of the hemiester was provided by its cyclization to the corre-
sponding 1-phenylnaphthalene derivative 13 with the sultam ring in position 6. The structure of 13 was

819
Molecules 2000, 5
proven by:
(a) analytical data;
1
(b) IR, H-NMR and mass spectra (cf. Experimental and Table 1);
O2S
N
(c) No fragment of m/e 210 was obtained (
, C H O NS); which is a reliable proof
10 12 2
that the sultam ring is in position 6 of the 1-phenylnaphthalene and not in position 4'. Furthermore, the
presence of five and not four adjacent hydrogen atoms [6] revealed the presence of an unsubstituted
phenyl group (cf. mechanism [2b]).
SO2
N
COPh
6
SO2
SO2
N
N
COOEt
CH2COOH
CH2COOH
COOEt
Ph
Ph
12
11
SO2
N
Ph
CH2COOH
COOH
COOEt
.H2O
Ph
18
N
N
SO2
OCOCH3
13
Ph
SO2
COOH
Ph
COOH
N
SO2
OCSNHPh
16
N
SO2
O
O
OH
Ph
14
O
19
Ph
Ph
COOCH3
COOH
N
SO2
N
SO2
OMe
OMe
15
17
Scheme 3.

820
Cyclization of the predominant (E-) hemiester (11) using sodium acetate and acetic anhydride [7]
Molecules 2000, 5
gave
4-acetoxy-2-ethoxycarbonyl-1-phenyl-6-(tetrahydro-1,2-thiazin-1,1-dioxide-2-yl)-naphthalene
(13). Compound 13 was hydrolyzed with aqueous sodium hydroxide (8%) to give the phenolic acid 14.
The latter acid was either treated with phenyl isothiocyanate in benzene to give 16 or methylated to
give methoxy ester 15. The latter was hydrolyzed with sodium hydroxide (2N) to give 2-carboxy-4-
methoxy-1-phenyl-6-(tetrahydro-1,2-thiazine-1,1-dioxide-2-yl)naphthalene (17) (cf. Scheme 3).
o
Saponification of the (E-) hemiester 11 with 2N sodium hydroxide (at 50-60 C) gave the dibasic
acid 18 in 87% yield. Use more of concentrated alkali or alcoholic alkali was not successful. This may
be due to the destruction of sultam ring. The dibasic acid was converted by refluxing with acetic anhy-
dride to the corresponding cyclic anhydride which exhibited the expected carbonyl coupling bands
(1830 and 1780 cm-1) [4,6].
Biological testing of all reported compounds, in particular for antitumor and antiepileptic activity, is
currently under way and results will be published elsewhere.
Experimental
General
All melting points were determined on a Electrothermal melting point apparatus and are uncor-
1
rected. IR spectra (KBr disks) were recorded on a Beckman IR 4220 spectrophotometer. H-NMR
spectra were recorded on a Varian EM 390-90 MHz. spectrometer and chemical shifts are expressed in
d (ppm) units using TMS as internal reference. Electronic absorption spectra were recorded in ethanol
solutions a Shimadzu graphic printer Pr-1 spectrophotometer. Mass spectra were recorded using a
GCMS-QP 1000 EX Shimadzu spectrometer. The Microanalytical units of Cairo University and of the
National Research Center performed elemental analyses.
4-(Trihydro-2H-1,2-thiazole-1,1-dioxide-2-yl)benzophenone (1)
4-Aminobenzophenone (1.97g, 0.01 mol) was fused with oxathiolan-2,2-dioxide (1.2 g, 0.01 mol) at
o
90-100 C in oil bath for one hour. The reaction mixture changed to yellow, then brownish oil, which
solidified. This solid was washed with hydrochloric acid and then with water. Yield 69%. Compound 1
had mp. 230-32oC (methanol), Found for C16H15NO3S (301.36): C, 63.51; H, 4.80; N, 4.80 and S,
1
10.10. Calcd.: C, 63.77; H, 5.01; N, 4.65; S, 10.63. H NMR: 1.7 (m, 2H, CH2CH2SO2), 2.6 (t, 2H,
NCH2), 3.2 (t, 2H, CH2SO2) and 7.4-7.7 (m, 9H, ArH’s)[8]. UV: l max 218 (log e = 4.47), 285 (log e =
4.32) and 332 (log e = 4.90) nm ; IR (cm-1) 1648 (CO), 1157 (SO ), 1317 (SO asym.), 1283 (sultam
2
2
band) and 738-705 (5 phenylic adjacent H atoms).

821
Molecules 2000, 5
4-(3,5-Dimethyl-1',2'-thiazine-1',1'-dioxide-2-yl)benzophenone (2)
4-Aminobenzophenone (1.97 g, 0.01 mol) was fused with 4,6-dimethyl-1,2-oxathiin-2,2-dioxide
o
(1.6g, 0.01 mol) at 110 C for one hour in an oil bath. The solid formed was washed with dil. hydro-
chloric acid and then with water. Yield: 35%. Compound 2 had mp. 185-86oC (methanol), Found for
C19H17NO3S (339.41): C, 66.80; H, 5.00; N, 3.90; S, 9.50. Calcd.: C, 67.23; H, 5.40; N, 4.12; S, 9.44.
UV l max 245 (log e = 4.00) and 334 (log e = 4.03); IR (cm-1) 1658 (CO), 1581 (conjugated double
bond of the sultam ring), 1280 (sultam ring).
4-Aminobenzophenone cyanoacetohydrazone (3)
To a mixture of 4-aminobenzophenone (1.97g, 0.01 mol) and cyanoacetohydrazide [8] (0.99g, 0.01
mol) in ethanol (50 mL), 3 drops of hydrochloric acid are added. The mixture was left at room tem-
perature for 72 hrs. Yield: 99%. Compound 3 had mp., 145-46oC. Found for C16H14N4O (278.31): C,
1
69.10; H, 5.10; N, 20.04. Calcd.: C, 69.05, H, 5.07; N, 20.13. H NMR: 3.8 (s, 2H, NH2), 4.2 (d, 2H,
CH2CN), 6.5-7.6 (m, 9H, ArH’s) and 9.6 (s, 1H, NH). IR (cm-1), 3460, 3375 (NH ), 2260 (CN), 1687
2
(CONH), 1140 (SO ), 1322 (SO asym).
2
2
4-(Phenyl thioureido)benzophenone (4)
A mixture of 4-aminobenzophenone (1.97g, 0.01 mol), phenyl isothiocyanate (1.35g, 0.01 mol) and
triethylamine (3 drops) in benzene (50 mL) was refluxed for 5 hrs. The solvent was evaporated under
o
vacuum to give an oily residue. It was triturated with light petroleum (60-80 C) to afford a solid.
Yield: 45%. Compound 4 had mp. 156-57oC (benzene-acetone). Found for C20H16N2OS (332.426): C,
72.50; H, 4.50; N, 8.00; S, 9.20. Calcd.: 72.26; H, 4.85; N, 8.42; S, 9.64. (UV l max217, 274 nm (log e=
4.16 and 4.06, respectively). IR (cm-1), 3322-3029 (NH), 1690 (CO), 1253-1023 (CS).
4-(Tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)benzophenone (6)
4-chloro-1-butanesulfonyl chloride (0.01 mol) was added dropwise at room temperature over 0.5 hr
to a stirred solution of 4-aminobenzophenone (1.97g, 0.01 mol) in benzene (20 mL) and pyridine (3
mL) to give 4-benzoyl-4-chlorobutanesulfonanilide (5). Compound 5 had mp., 105-106oC (benzene-
petroleum ether). Found for C17H18ClNO3 (351.85): C, 58.30; H, 5.20; N, 3.92; S, 9.00. Calcd.: C,
58.03; H, 5.12; N; 3.98; S, 9.11. Its 2,4-DNP derivative, mp. 233-34oC (acetic acid, 60%). Found for
C23H22ClN5O6S (531.98): C, 52.00; H, 4.10; N, 13.20; S, 6.00. Calcd.: C, 51.93; H, 4.16; N, 13.16; S,
6.03.
A solution of 5 was warmed at 40-50oC for 3 hrs with sodium hydroxide (2N) to give 6 [4]. Yield:
63%, mp. 136-37oC (benzene). Found for C17H17NO3S (315.39): C, 64.70; H, 5.30; N, 4.40; S, 9.90.
1
Calcd., C, 64.74; H, 5.43; N, 4.44; S, 10.15. H NMR: 1.8 (m, 2H, CH2CH2SO2), 2.3 (m, 2H,

822
Molecules 2000, 5
SO2CH2CH2CH2), 3.2 (t, 2H, SO2CH2), 3.8 (t, 2H, NCH2) and 7.2-7.7 (m, 9H, ArH’s. IR (cm-1), 1690
(CO), 1325 (SO N), 1280 (sultam) and 770-700 (five adjacent hydrogen atoms). UV l 235,
2
max
305nm (log e = 4.68 and 4.89, respectively). Its DNP had mp. 275-76oC (acetic acid). Found for
C23H21N5O6S (495.52); C, 56.10; H, 4.40; N, 13.60; S, 6.20. Calcd.: C, 55.75; H, 4.26; N, 14.19; S,
6.67.
4-(Tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)benzophenonecyanoacetohydrazone (7)
Prepared from 6 in a similar fashion as above, yield 75%. Mp. 122-23oC (ethanol). Found for
C20H20N4O3S (396.47): C, 60.50; H, 5.10; N, 14.00; S, 8.20. Calcd.: C, 60.59; H, 5.08; N, 14.13, S,
1
8.08. H NMR: 1.8 (m, 2H, SO2CH2CH2), 2.3 (m, 2H, SO2CH2CH2CH2), 3.2 (t, SO2CH2), 3.8 (t,
NCH2), 7.4-7.7 (m, 9H, ArH’s), 9.3 (s, 1H, NHCO).
(a) The hydrazone derivative 7 (0.01 mol) was coupled with benzenediazonium chloride (0.01 mol)
to give 8, yield at room temperature 64%, mp. 130-31oC (acetic acid). Found for C26H24N6O3S
(500.58): C, 61.40; H, 4.80; N, 16.80; S, 6.40. Calcd.: C, 61.38; H, 4.83; N, 16.78; S, 6.40. IR (cm-1),
2152 (CN), 1648 (CONH) and 1280 (sultam).
(b) To hydrazone derivative 7 (0.01 mol), benzaldehyde (0.01 mol) in ethanol (20 mL) and 2 drops
of piperidine were added. The mixture was refluxed for 30 minutes on a water bath. After cooling, the
solid was collected and crystallized to give 9 (73.5%), mp. 230-31oC (ethanol). Found for
C26H24N4O3S (472.57): C, 66.30; H, 5.10; N, 11.70; S, 6.40. Calcd.: C, 66.08; H, 5.12; N, 11.85; S,
6.76. IR (cm-1), 2152 (CN), 1648 (CONH) and 1280 (sultam).
(c) To hydrazone derivative 7 (0.01 mol), salicylaldehyde (0.01 mol) in ethanolic sodium ethoxide
solution [prepared from sodium metal (1.1 g-atom) in ethanol (20 mL)] was added. The mixture was
refluxed for 2 hrs., then cooled. The reaction mixture was acidified with hydrochloric acid to give 10,
yield 55%, mp. 243-44oC (ethanol). Found for C27H23N3O5S (501.56): C, 64.50; H, 4.60; N, 8.80, S,
6.70. Calcd.: C, 64.65; H, 4.62; N, 8.38; S, 6.39. IR (cm-1) 3446 (NH), 1700, 1648 (two CO) and 1282
(sultam ).
3-Ethoxycarbonyl-4-phenyl-4-(4'-tetrahydro-1,2-thiazine-1,1-dioxide-2-yl)phenyl-3-butenoic acids (11
and 12)
To a cooled stirred mixture of ketone 6 (0.01 mol) and diethyl succinate (0.02 mol) in t-butanol (15
mL), potassium t-butoxide was added dropwise [prepared from 1.2 g-atom potassium and t-butanol (50
o
mL)]. After 72 hrs, the reaction mixture was heated at 65-70 C for one hour, then worked up as usual
[2b] to give an acidic brown viscous oily product (yield ~ 7.3g, 82%). The (E-) (11) and (Z-) (12) iso-
meric hemiesters were separated by fractional crystallization.
Compound 11 had mp. 144-45oC (benzene-acetone). Found for C23H25NO6S (443.52): C, 62.00; H,
5.50; N, 3.30; S, 7.60. Calcd.: C, 62.28; H, 5.64; N, 3.16; S, 7.23. IR (cm-1), 3300-2600 (g OH), 1700-
1620 (CO), 1270 (sultam).
Compound 12 had m.p. 108-109oC (benzene). Found for C23H25NO6S (443.52): C, 62.40; H, 5.50;

823
Molecules 2000, 5
N, 3.30; S, 7.50. Calcd.: C, 62.28; H, 5.64, N, 3.16; S, 7.23. IR (cm-1), 3600-2500 (OH), 1700-1640
(CO), 1280 (sultam).
Determination of the relative ratio of the two (E-) and (Z-) hemiesters by electronic absorption spec-
troscopy [5]
Values for Eobs/E1 were plotted vs. the values for E2s/E1 where Eobs is the observed optical density of
the mixture and E1 and E2 are the optical densities of the hemiesters 11 and 12 respectively, at the
same wavelength. A straight line was obtained from which the ratio of 5.9/1 was calculated. This is
almost the same ratio as that obtained experimentally by fractional crystallization.
Cyclization of the (E-) hemiester
A mixture of the (E-) hemiester (1 mol) fused sodium acetate (1.2 mol) and acetic anhydride (30
mL/ 1g sodium acetate) was left overnight with occasional shaking at room temperature. The tem-
perature was gradually raised to 70-80oC for 3hrs. The neutral cyclized product 13 was isolated and
had mp. 122-23oC (ethanol). Found for C25H25NO6S.H2O (485.56): C, 62.00; H, 5.40; N, 3.00; S, 6.80.
1
Calcd.: C, 61.84; H, 5.19; N, 2.88; S, 6.61. Mass spectrum, m/e = 485 and H NMR: 1.2 (t, 3H,
CH3CH2O), 1.8 (m, 2H, SO2CH2CH2), 2.3 (m, 2H, CH2(CH2)2SO2, 3.2 (t, 2H, SO2CH2), 3.5 (t, 2H,
NCH2), and 7.0-7.8 (m, 9H, ArH’s)9. IR (cm-1), 1760 (CO), 1290 (sultam ring), 740-700 (five adjacent
hydrogen atoms).
Conversion of the acetoxy ester 13 into methoxy acid 17
o
The acetoxy ester was hydrolysed with 2N sodium hydroxide on water-bath (70 - 80 C) for two hrs.
The hydroxy acid 14 (1 mol) was methylated by refluxing for 10 hrs with dimethyl sulphate (5 mol)
and potassium carbonate (6 mol) in dry acetone. The methoxy ester was hydrolyzed to the corre-
sponding acid by warming for 3 hrs with 8% sodium hydroxide, followed by cooling and acidification.
Compound 14 had mp. 225-26oC (acetic acid). Found for C21H19NO5S (397.45): C, 63.20; H, 5.10;
N, 3.40; S, 7.70. Calcd.: C, 63.47; H, 4.81; N, 3.52; S, 8.06.
Compound 15 had mp. 167-68o (methanol). Found for C23H23NO5S (425.50): C, 64.70; H, 5.00; N,
3.60, S, 7.90. Calcd.: C, 64.92; H, 5.44; N, 3.29; S, 7.52.
Compound 17 had mp., 120-21oC (acetic acid). Found for C22H21NO5S (411.48): C, 63.90; H, 5.30;
-1
N, 3.40; S, 7.60. Calcd.: C, 64.23; H, 5.14; N, 3.40; S, 7.78. IR (cm ), 1725 (CO), 1295 (sultam) and
740- 700 (five adjacent hydrogen atoms).
2-Carboxy-4(N-phenylthiocarbamoyl)-1-phenyl-6-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)-
naphthalene (16)
A mixture of hydroxynaphthoic acid derivative 14 (0.01 mol), phenyl isothiocyanate (0.01 mol) and

824
Molecules 2000, 5
3 drops of triethylamine in dry benzene (30 mL) was refluxed for 5 hrs. The benzene was evaporated
under reduced pressure to give yellow solid 16, yield 71%. It had mp. 133-34oC (benzene-acetone).
Found for C28H24N2O5S2 (532.64): 62.90; H, 4.90; N, 5.40; S, 11.90. Calcd.: C, 63.14; H, 4.54; N,
5.26; S, 12.01. IR (cm-1), 3247-2800 (OH), 1725(CO), 1290 (sultam) and 744-701 (five adjacent hy-
drogen atoms).
Saponification of the (E-) hemiester to the corresponding dibasic acid 18 and anhydride 19
o
The (E-) hemiester (0.1 mol) was left in NaOH (2N, 50 mL) for about 72 hrs., then kept 60-80 C
for one hour. The dibasic acid 18 was refluxed with a mixture of acetic anhydride (7 mL) and acetyl
chloride (5 mL) on a sand bath for 30 minutes, to give the corresponding anhydride (19).
Compound 18 had mp., 175-76oC (benzene-acetone). Found for C21H21NO6S (415.47): C, 60.20; H,
5.10; N, 3.90; S, 7.20. Calcd.: 60.72; H, 5.08; N, 3.37; S, 7.85. 1H NMR: 1.7 (m, 2H, CH2CH2SO2), 2.3
(m, 2H, CH2(CH2)2SO2), 3.2 (t, 2H, SO2CH2), 3.5 (t, 2H, NCH2), 7.1-7.4 (m, 9H, ArH’s) and 12.5 (s,
-1
2H, (COOH)2. IR (cm ), 3446-2500 (g OH), 1720-1656 (CO ), 1276 (sultam), 745-707 (five adjacent
hydrogen atoms).
Compound 19 had mp. 137-38oC (benzene-peteroleum ether). Found for C21H19NO5S (397.45): C,
-1
63.20; H, 5.00; N, 3.90; S, 8.30. Calcd.: C, 63.46; H, 4.81; N, 3.52; S, 8.07. IR (cm ), 1840,1780
(CO-O-CO), 1280 (sultam ring) and 750-700 (five adjacent hydrogen atoms).
Table 1. Mass spectra of compounds 1, 3, 6, 11, 12 and 13.
+
+
+1
+1
);
1
301 (20, C16H15NSO3 ); 224 (12, C10H10NSO3 197 (100, C9H10NSO2 ); 180 (5, C13H9O );
+
+
120 (8, C3H6NSO2 ); 77 (16, C6H5 ).
+
+
+
3
278 (100, C16H14ON4 ); 238(21.69, C14H12ON3 ); 210(37.08, C13H12N3 ), 180 (29.44,
+
C13H10N+); 119 (1.87, C7H5ON+); 77 (16.64, C6H5 ).
+
+
+
6
315 (100, C17H17NSO3 ; 238 (47.13, C11H12NSO3 ); 210(14.93 C10H12NSO2 ); 132 (19,
+
C9H10N+); 105 (19,C7H5O+); 77(16, C6H5 ).
443 (12.1, C23H25NSO6 ); 339 (33.6, C22H25NSO4+1); 379 (1.8, C23H25NO4 ); 365 (14.4,
+
+
11
+
+1
+
+
C22H23NO4 ); 325 (100, C19H18NO4 ); 308 (7.9, C19H16O4 ); 144 (1.6, C6H8O4 ); 134 (0.7,
+
+
C4H8NSO2 ); 77 (1.5, C6H5 ).
+
+
12
13
443 (12.80, C23H25NSO6 ); 325 (100, C19H18O4N+1); 308 (13.4, C19H16O4 ); 139 (5.2,
C6H2O4+1); 134 (3.4, C4H8NSO2 ); 77(7.9, C6H5 ).
485 (100, C25H25NSO6·H2O+); 467 (5, C25H25NSO6 ); 404 (5, C25H25NO4+1); 361 (5,
+
+
+
C23H22NO+1).

825
Molecules 2000, 5
References and Notes
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Samples Availability: Available from the authors.
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