Tetrahedron Letters p. 190 - 193 (2017)
Update date:2022-08-05
Topics:
Hao, Youwu
Zhou, Gaohui
Wu, Wei
Zhang, Yang
Tao, Liming
Yao, Jianhua
Xu, Wenping
A series of adenosine analogues were synthesized and their biological evaluation was tested against Coxsackie virus B3 (CVB3) and Herpes simplex virus type 1(HSV-1) in HEp-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were calculated. Analogues with piperazine derivatives 8b showed promising activities against CVB3 with a lower IC50value and higher selectivity index, their efficacy was better than that of the commercialized medicine, Ribavirin. These described adenosine analogues exhibit potent antiviral activities against several viruses, and offer new leads for further development.
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