Int. J. Mol. Sci. 2021, 22, 7678
20 of 21
References
1.
2.
3.
Abu-Hashem, A.A.; Gouda, M.A. Synthesis, anti-inflammatory and analgesic evaluation of certain new 3a,4,9,9a-tetrahydro-4,9-
benzenobenz[f]isoindole-1,3-diones. Arch. Pharm. 2011, 344, 543–551. [CrossRef] [PubMed]
Su, M.; Cao, J.; Huang, J.; Liu, S.; Im, D.S.; Yoo, J.W.; Jung, J.H. The in vitro and in vivo anti-inflammatory effects of a phthalimide
PPAR-γ agonist. Mar. Drugs 2017, 15, 7. [CrossRef]
Ignasik, M.; Bajda, M.; Guzior, N.; Prinz, M.; Holzgrabe, U.; Malawska, B. Design, synthesis and evaluation of novel 2-
(Aminoalkyl)-isoindoline-1,3- dione derivatives as dual-binding site acetylcholinesterase inhibitors. Arch. Pharm. 2012, 345,
4.
5.
6.
Panek, D.; Wie¸ckowska, A.; Pasieka, A.; Godyn´, J.; Jon´czyk, J.; Bajda, M.; Knez, D.; Gobec, S.; Malawska, B. Design, synthesis,
and biological evaluation of 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones derivatives as potential disease-modifying
multifunctional anti-Alzheimer agents. Molecules 2018, 23, 347. [CrossRef]
Guzior, N.; Bajda, M.; Skrok, M.; Kurpiewska, K.; Lewin´ski, K.; Brus, B.; Pišlar, A.; Kos, J.; Gobec, S.; Malawska, B. Development
of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with
neuroprotective properties. Eur. J. Med. Chem. 2015, 92, 738–749. [CrossRef]
Godin, A.M.; Araújo, D.P.; Menezes, R.R.; Brito, A.M.S.; Melo, I.S.F.; Coura, G.M.E.; Soares, D.G.; Bastos, L.F.S.; Amaral, F.A.;
Ribeiro, L.S.; et al. Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide
moiety, in experimental models of inflammatory pain and edema. Pharmacol. Biochem. Behav. 2014, 122, 291–298. [CrossRef]
7.
Godin, A.M.; Araújo, D.P.; César, I.C.; Menezes, R.R.; Brito, A.M.S.; Melo, I.S.F.; Coura, G.M.E.; Bastos, L.F.S.; Almeida, M.O.;
Byrro, R.M.D.; et al. Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and
edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms. Eur. J. Pharmacol. 2015
,
8.
9.
Sharma, U.; Kumar, P.; Kumar, N.; Singh, B. Recent Advances in the Chemistry of Phthalimide Analogues and their Therapeutic
Potential. Mini-Rev. Med. Chem. 2010, 10, 678–704. [CrossRef] [PubMed]
Bach, D.H.; Liu, J.Y.; Kim, W.K.; Hong, J.Y.; Park, S.H.; Kim, D.; Qin, S.N.; Luu, T.T.T.; Park, H.J.; Xu, Y.N.; et al. Synthesis and
biological activity of new phthalimides as potential anti-inflammatory agents. Bioorg. Med. Chem. 2017, 25, 3396–3405. [CrossRef]
10. Godin, A.M.; Araújo, D.P.; Menezes, R.R.; de Brito, A.M.S.; Melo, I.S.F.; Coura, G.M.E.; Bastos, L.F.S.; Amaral, F.A.; Teixeira, M.M.;
de Fátima, Â.; et al. 2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and
cytokine and chemokine production in a murine model of articular inflammation. Pharmacol. Rep. 2017, 69, 691–695. [CrossRef]
11. Batista, C.R.A.; Godin, A.M.; Melo, I.S.F.; Coura, G.M.E.; Matsui, T.C.; Dutra, M.M.G.B.; Brito, A.M.S.; Canhestro, W.G.; Alves,
R.J.; Araújo, D.P.; et al. The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide
exhibit activity in experimental models of inflammatory and neuropathic pain. Pharmacol. Rep. 2019, 71, 1177–1183. [CrossRef]
12. Magli, E.; Ke˛dzierska, E.; Kaczor, A.A.; Bielenica, A.; Severino, B.; Gibuła-Tarłowska, E.; Kotlin´ska, J.H.; Corvino, A.; Sparaco, R.;
Esposito, G.; et al. Synthesis, docking studies, and pharmacological evaluation of 2-hydroxypropyl-4-arylpiperazine derivatives
as serotoninergic ligands. Arch. Pharm. 2021, 354, 2000414. [CrossRef]
13. Wójcicka, A.; Redzicka, A. An overview of the biological activity of pyrrolo[3,4-c]pyridine derivatives. Pharmaceuticals 2021, 14,
14. Abdel-Aziz, A.A.M.; El-Azab, A.S.; Ghiaty, A.H.; Gratteri, P.; Supuran, C.T.; Nocentini, A. 4-Substituted benzenesulfonamides
featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition. Bioorg. Chem. 2019, 83,
15. Stiz, D.; Corrêa, R.; D’Auria, F.D.; Simonetti, G.; Cechinel-Filho, V. Synthesis of cyclic imides (methylphtalimides, carboxylic acid
phtalimides and itaconimides) and evaluation of their antifungal potential. Med. Chem. 2016, 12, 647–654. [CrossRef] [PubMed]
16. Hassanzadeh, F.; Jafari, E. Cyclic imide derivatives: As promising scaffold for the synthesis of antimicrobial agents. J. Res. Med.
´
˙
17. Szczukowski, Ł.; Krzyzak, E.; Zborowska, A.; Zaja˛c, P.; Potyrak, K.; Peregrym, K.; Wiatrak, B.; Marciniak, A.; Swia˛tek, P. Design,
synthesis and comprehensive investigations of pyrrolo[3,4-d]pyridazinone-based 1,3,4-oxadiazole as new class of selective cox-2
18. Jaafar, A.-H.; Zuhair, M.-E.; Sadeq, A.-T.; Rand, A.-Q. Synthesis of isoindoline-1,3-dione derivatives as cyclooxygenase (Cox) S
inhibitors. Int. J. Pharma Bio Sci. 2021, 11. [CrossRef]
´
˙
19. Szkatuła, D.; Krzyzak, E.; Mogilski, S.; Sapa, J.; Filipek, B.; Swia˛tek, P. Bioresearch of new 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-
˙
20. Krzyzak, E.; Szkatuła, D.; Wiatrak, B.; Ge˛barowski, T.; Marciniak, A. Synthesis, cyclooxygenases inhibition activities and
interactions with BSA of N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones derivatives. Molecules 2020, 25, 2934. [CrossRef]
21. Dogruer, D.S.; Kupeli, E.; Yesilada, E.; Sahin, M.F. Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-
phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents. Arch. Pharm. 2004, 337, 303–310.
22. Zarghi, A.; Arfaei, S. Selective COX-2 inhibitors: A review of their structure-activity relationships. Iran. J. Pharm. Res. 2011, 10,