Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents

DOI: 10.1021/jm049141s

Source and publish data:

Journal of Medicinal Chemistry p. 1596 - 1609 (2005)

Update date:2022-08-05

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Authors:

Nie, Zhe

Perretta, Carin

Lu, Jia Lu, Jia

Su, Ying

Margosiak, Stephen

Gajiwala, Ketan S.

Cortez, Joseph

Nikulin, Victor

Yager, Kraig M.

Appelt, Krzysztof

Chu, Shaosong

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Article abstract of DOI:10.1021/jm049141s

Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. FabH, β-ketoacyl-ACP synthase III, is a particularly attractiv

Full text of DOI:10.1021/jm049141s

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