Stereocontrolled Elaboration of Quaternary Carbon Centers through the Asymmetric Michael Reaction Using Chiral Imines: Enantioselective Synthesis of (+)-Aspidospermidine

DOI: 10.1021/jo00088a008

Source and publish data:

Journal of Organic Chemistry p. 2292 - 2303 (1994)

Update date:2022-08-05

Topics:

Authors:

Desmaeele, Didier

d'Angelo, Jean

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Article abstract of DOI:10.1021/jo00088a008

An enantioselective synthesis of (+)-aspidospermidine (1b) has been developed.The key strategic element was the stereocontrolled elaboration of quaternary carbon centers through the asymmetric Michael reaction, using chiral imines under neutral conditions

Full text of DOI:10.1021/jo00088a008

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