Journal of Medicinal Chemistry p. 2485 - 2493 (1993)
Update date:2022-09-26
Topics:
Ellingboe, John W.
Lombardo, Louis J.
Alessi, Thomas R.
Nguyen, Thomas T.
Guzzo, Frieda
et al.
A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-<(5-Chloronaphthalen-2-yl)methyl>-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.
View MoreHangzhou Gangjin Chemical Co.,Ltd.(expird)
Contact:+86-571-85109780
Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.
Contact:86-312-3262436
Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Zhengzhou Institute of Chiral Pharmer Research Co., Ltd.
Contact:86-371-55219111
Address:15 Floor, 2 Building, Central China Technovalley, Zhongyuan West Road
Jinan Jiaquan Chemical Co.,Ltd
Contact:+86-531-62318366
Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
BAODING SINO-CHEM INDUSTRY CO.,LTD
Contact:0312-5956088
Address:NO.8 FUXING ROAD,CHINA
Doi:10.1021/ja00739a037
(1971)Doi:10.1021/ja003508a
(2001)Doi:10.1016/S0022-328X(01)00899-3
(2001)Doi:10.1016/S0957-4166(00)00374-8
(2000)Doi:10.1016/S0031-9422(00)84333-2
(1971)Doi:10.1021/ol007032b
(2001)