Journal of Medicinal Chemistry p. 2485 - 2493 (1993)
Update date:2022-09-26
Topics:
Ellingboe, John W.
Lombardo, Louis J.
Alessi, Thomas R.
Nguyen, Thomas T.
Guzzo, Frieda
et al.
A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-<(5-Chloronaphthalen-2-yl)methyl>-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.
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