Promiscuous lipase catalyzed a new P–C bond formation: Green and efficient protocol for one-pot synthesis of α-aminophosphonates

Article abstract of DOI:10.1002/hc.21408

α-Aminophosphonates are valuable substructures with important biological and pharmacological properties. Lipase catalytic promiscuity is a new method in the organic synthesis for the preparation of α-aminophosphonates via multicomponent reaction in one pot. This efficient, simple, and eco-friendly method proceeds in the presence of immobilized Candida Antarctica lipase as catalyst under solvent-free conditions at room temperature. The new α-aminophosphonates are synthesized in high yields (up to 96%). Moreover, enzymatic-catalyzed P–C bond formation through a Kabachnik-Fields reaction was achieved for the first time.