Bioorganic and Medicinal Chemistry Letters p. 599 - 603 (2001)
Update date:2022-07-30
Topics:
Kim, Hea Ok
Kim, Yun Ha
Suh, Hwal
Jeong, Lak Shin
Novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-β-N6-methyladenine (ent-22a) and D-α-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity.
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